Dose Table
See Sialanar®’s dosing table in full
Sialanar® is licensed for the symptomatic treatment of severe sialorrhoea in children and adolescents aged 3 years and older with chronic neurological disorders.1
Patients should start titration from dose level 1, increasing every 7 days until efficacy is balanced with undesirable effects1
- The dosing schedule is based upon the weight of the child, starting with dose level 1 at 16mcg/kg per dose glycopyrronium bromide three times per day, then increasing the dose as per doses shown every 7 days
- Dose titration should be continued until efficacy is balanced with undesirable effects and amended up or down, as appropriate, to a maximum individual dose of 80mcg/kg glycopyrronium bromide or 6ml (2.4mg glycopyrronium bromide) TDS
- Doses should be reduced by 30% in patients with mild to moderate renal impairment (eGFR <90 - ≥30 ml/min/1.73m2) as per doses shown here
- Undesirable effects may be minimised by using the lowest effective dose necessary to control symptoms
Dose titrations should be conducted in discussion with the carer to assess both efficacy and undesirable effects until an acceptable maintenance dose is achieved.
Dose level should be titrated up until drooling is appropriately managed but reduced in the event of a known anticholinergic reaction.
- Oral preparations are not interchangeable on a microgram-for-microgram basis due to differences in bioavailability.
- Sialanar® oral solution has approximately 25% higher bioavailability and therefore equivalent doses will be lower than for tablets and generic oral solutions.
- The prescriber should state the specific branded or generic oral preparation to be used.
To ensure your patients receive a product designed for children, prescribe as Sialanar®
- Sialanar® should be administered three times per day:
- Dose 1 – Morning
- Dose 2 – Afternoong
- Dose 3 – Evening
- 1 hour before mealtime OR 2 hours after OR at consistent times with respect to food intake
Switching Patients to Sialanar®
Guidance on switching patients from hyoscine or 1mg/5ml glycopyrronium bromide oral solutions to Sialanar®
